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Index > Protein center > Vtcn1(Gene name) > Mouse
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  • Vtcn1 (Gene name),
  • V-set domain containing T-cell activation inhibitor 1 (Protein name ),  VTCN1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vtcn1(B7h4);
    Protein name:
    V-set domain containing T-cell activation inhibitor 1;
    Alternative:
    Protein B7S1;Immune costimulatory protein B7-H4;T cell costimulatory molecule B7x;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor Expressed at the cell surface. A soluble form has also been detected.
    Protein Attributes:
    Sequence length:
    283
    Sequence:
    50:
    MASLGQIIFW | SIINIIIILA | GAIALIIGFG | ISGKHFITVT | TFTSAGNIGE | 
    100:
    DGTLSCTFEP | DIKLNGIVIQ | WLKEGIKGLV | HEFKEGKDDL | SQQHEMFRGR | 
    150:
    TAVFADQVVV | GNASLRLKNV | QLTDAGTYTC | YIRTSKGKGN | ANLEYKTGAF | 
    200:
    SMPEINVDYN | ASSESLRCEA | PRWFPQPTVA | WASQVDQGAN | FSEVSNTSFE | 
    250:
    LNSENVTMKV | VSVLYNVTIN | NTYSCMIEND | IAKATGDIKV | TDSEVKRRSQ | 
    283:
    LQLLNSGPSP | CVFSSAFVAG | WALLSLSCCL | MLR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    E1079h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    E1079m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    E1079r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    U1079m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    U1079r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    U1079h
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    P1079Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    P1079Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Cat.:
    P1079Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
    Protein for Mouse V-set domain containing T-cell activation inhibitor 1
    Protein for Mouse V-set domain containing T-cell activation inhibitor 1
    Protein for Mouse V-set domain containing T-cell activation inhibitor 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
      Sica G.L. , Choi I.-H. , Zhu G. , Tamada K. , Wang S.-D. , Tamura H. , Chapoval A.I. , Flies D.B. , Bajorath J. , Chen L.
      Immunity18:849-861(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: BALB/c.
      tissue: Spleen.
    2. 2.
      "B7S1, a novel B7 family member that negatively regulates T cell activation."
      Prasad D.V.R. , Richards S. , Mai X.M. , Dong C.
      Immunity18:863-873(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION;GPI-ANCHOR
    3. 3.
      "B7x: a widely expressed B7 family member that inhibits T cell activation."
      Zang X. , Loke P. , Kim J. , Murphy K. , Waitz R. , Allison J.P.
      Proc. Natl. Acad. Sci. U.S.A.100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      strain: FVB/N.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Blastocyst.
      tissue: Oviduct.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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